Category: Herzschwäche

Study: Heart Failure The clinical and hemodynamic effects of coenzyme Q10 in congestive cardiomyopathy. Sacher HL; Sacher ML; Landau SW; Kersten R; Dooley F; Sacher A; Sacher M; Dietrick K; Ichkhan K Am J Ther 1997 Feb-Mar;4(2-3):66-72 Despite major advances in treatment congestive heart failure (CHF) is still one of the major causes of morbidity […] More

Study: Heart Failure Usefulness of coenzyme Q10 in clinical cardiology: a long-term study. Langsjoen H; Langsjoen P; Langsjoen P; Willis R; Folkers K Molecular Aspects of Medicine 1994;15 Suppl:s165-75 Over an eight year period (1985-1993), we treated 424 patients with various forms of cardiovascular disease by adding coenzyme Q10 (CoQ10) to their medical regimens. Doses […] More

Study: Heart Failure L-carnitine treatment for congestive heart failure–experimental and clinical study. Kobayashi A; Masumura Y; Yamazaki N Japanese Circulation Journal 1992 Jan;56(1):86-94 To evaluate the therapeutic efficacy of l-carnitine in heart failure, the myocardial carnitine levels and the therapeutic efficacy of l-carnitine were studied in cardiomyopathic BIO 14.6 hamsters and in patients with chronic […] More

Study: Heart Failure Randomized, double-blind, placebo-controlled study of ascorbate on the preventive effect of nitrate tolerance in patients with congestive heart failure. Watanabe H; Kakihana M; Ohtsuka S; Sugishita Y Circulation 1998 Mar 10;97(9):886-91 BACKGROUND: Reduced cGMP production caused by increased superoxide has been proposed as a mechanism of nitrate tolerance during continuous nitrate therapy. […] More

Study: Heart Failure A randomised, double-blind, placebo-controlled trial of L-carnitine in suspected acute myocardial infarction. Singh RB; Niaz MA; Agarwal P; Beegum R; Rastogi SS; Sachan DS Postgraduate Medical Journal 1996 Jan;72(843):45-50 In a randomised, double-blind placebo-controlled trial, the effects of the administration of oral L-carnitine (2 g/day) for 28 days were compared in the […] More

Study: Heart Failure Role of oxidative stress in transition of hypertrophy to heart failure. Dhalla AK; Hill MF; Singal PK Journal of the American College of Cardiology 1996 Aug;28(2):506-14 OBJECTIVES: In an attempt to define the role of increased oxidative stress in the transition from compensatory hypertrophy to heart failure, this study examined the effects […] More

Study: Heart Failure Controlled study on the therapeutic efficacy of propionyl-L-carnitine in patients with congestive heart failure. Mancini M; Rengo F; Lingetti M; Sorrentino GP; Nolfe G Arzneimittelforschung 1992 Sep;42(9):1101-4 A double-blind phase II study of propionyl-L-carnitine (CAS 17298-37-2) versus placebo was carried out on a group of 60 patients with mild to moderate (II […] More

Study: Heart Failure Neutrophil superoxide anion–generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy. Ellis GR; Anderson RA; Lang D; Blackman DJ; Morris RH; Morris-Thurgood J; McDowell IF; Jackson SK; Lewis MJ; Frenneaux MP Journal of the American College of Cardiology 2000 Nov 1;36(5):1474-82 OBJECTIVES: […] More

Study: Heart Failure Acute and chronic effects of propionyl-L-carnitine on the hemodynamics, exercise capacity, and hormones in patients with congestive heart failure. Anand I; Chandrashekhan Y; De Giuli F; Pasini E; Mazzoletti A; Confortini R; Ferrari R Cardiovasc Drugs Ther 1998 Jul;12(3):291-9 Carnitine is an important cofactor in the intermediary metabolism of the heart, and […] More

Study: Heart Failure Acute effects of vitamin C on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure. Ellis GR; Anderson RA; Chirkov YY; Morris-Thurgood J; Jackson SK; Lewis MJ; Horowitz JD; Frenneaux MP Journal of Cardiovascular Pharmacology 2001 May;37(5):564-70 Chronic heart failure (CHF) is characterized by a prothrombotic […] More